Sin-Hyeog Im, PhD.


Current affiliation:

Group leader/Professor, Academy of Immunology and Microbiology (AIM), Institute for Basic Science (IBS), and Pohang University of Science and Technology (POSTECH), Republic of Korea

Selected publications:

Probiotics, microbiota and Immune regulation.

  1. Toll-like receptor 5 ligand flagellin-based immunomodulatory therapy for allergic asthma. J Allergy Clin Immunol 2015. 2015 Aug 21. pii: S0091-6749(15)00952-5
  2. Salmonella typhimurium suppresses tumor growth via the pro-inflammatory cytokine  interleukin-1β. Theranostics. 2015 5(12) 1328-1342
  3. Family 5 extracellular solute-binding protein (ESbP) derived from Bifidobacterium longum KACC 91563 alleviates food allergy through suppression of mast cells. J Allergy Clin Immunol 2015. Sep 30. pii: S0091-6749(15)01240
  4. The probiotic mixture IRT5 ameliorates age-dependent colitis in rats. Int Immunopharmacol. 2015 Jun;26(2):416-22
  5. Lactobacillus Helveticus Suppresses Experimental Rheumatoid Arthritis by Reducing Inflammatory T Cell Responses. J Funct Foods 2015. 350-362
  6. Amelioration of Experimental Autoimmune Encephalomyelitis by Probiotic Mixture is Mediated by a Shift in T Helper Cell Immune Response.Clin Immunol. 2013,46(3):217-27.
  7. Prophylactic Effect of Probiotics on The Development of Experimental Autoimmune Myasthenia Gravis. Plos One. 2012;7(12):E52119
  8. Immune Disorders and its Correlation with Gut Microbiome. Immune Netw. 2012 Aug;12(4):129-38
  9. Lactobacillus Casei Enhances Type II Collagen/Glucosamine-Mediated Suppression of Inflammatory Responses in Experimental Osteoarthritis.Life Sci. 2011 Feb 14;88(7-8):358-66.
  10. Generation of Regulatory Dendritic Cells and CD4+Foxp3+ T Cells by Probiotics Administration Suppresses Immune Disorders.Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2159-64
  11. Lactobacillus Casei Potentiates Induction of Oral Tolerance in Experimental Arthritis. Mol Immunol. 2008 Nov;46(1):172-80.
  12. Lactobacillus Casei Suppresses Experimental Arthritis by Down-Regulating T Helper 1 Effector Functions.Mol Immunol. 2008 May;45(9):2690-9.

Immune Tolerance In Health And Disease

  1. TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse. J Cell Biol. 2015 Apr 13;209(1):143-62
  2. NAMPT suppresses glucose deprivation-induced oxidative stress by increasing NADPH levels in breast cancer. Oncogene. 2015 In press
  3. NFAT1 and Junb Cooperatively Regulate the IL-31 Gene Expression In CD4+ T Cells in Health And Disease. J Immunol, 2015: 194(4). 194(4): 1963-1974.
  4. 6-Methoxyflavone Suppresses T Cell Activation by Inhibiting NFAT1 Translocation into the Nucleus. J Immunol, 2014;193(6):2772-83.
  5. Hypoxia-Inducible Factor-2a is an Essential Catabolic Regulator of Inflammatory Rheumatoid Arthritis Plos Biology. 2014: 12(6)E1001881.
  6. Role of Blimp-1 in Programing the Effector Cells into IL-10 Producers. 2014. J Exp Med. 2014;211(9):1807-19
  7. Imageable Antigen-presenting Gold Nanoparticle Vaccines for Effective Cancer Immunotherapy in Vivo. Angew Chem Int Ed Engl. 2012 Aug 27;51(35):8800-5
  8. NFAT1 Induced Permissive Chromatin Modification Facilitates NF-Κb Mediated IL-9 Transactivation. J Biol Chem. 2012 May 4;287(19):15445-57
  9. Interaction of Ets-1 with HDAC1 Represses IL-10 Expression in T Helper 1 Cells. J Immunol. 2012;188(5):2244-253
  10. IGSF4 is a Novel TCRz-Chain-Interacting Protein that Enhances TCR-Mediated Signaling. J Exp Med. 2011 Nov 21;208(12):2545-60.


Expertise and research areas:

Probiotics-mediated Immune modulation, Regulatory lymphocytes, experimental immune disorders, mucosal immune tolerance