BILE ALT METABOLISM IN THE GUT: LESSONS FROM THE MICROBIOTA
APC Microbiome Institute, Ireland
The range and diversity of bile acids and their conjugated (either to Taurine or to glycine) salts is dictated by the gut microbiota. Besides their role in aiding the emulsification of lipids and the release of fat soluble vitamins, bile acids and their conjugated salts are now recognised as potent signalling molecules with the potential to influence health and disease status. They can act as ligands binding to receptors, they can influence their own synthesis through cross-talk with the liver, they can adjust transporter systems and nutrient uptake and they also play a role in determining gut microbial residency. Therefore bile metabolizing microbes have a central role in gut metabolism and gut health. We have investigated the role and the implications of bile acid metabolism in the regulation of host physiology through bile acid alterations and microbiome signatures. Here, we present our work in correlating microbial bile acid metabolism and disease states. We profile isolated potential bespoke probiotic strains isolated on the basis of either rational (genetic targeting to isolate certain BSH types and activities) or random (non-genetic selection for any bile acid modification) selection. These strains, their efffects on the gut microbiota, BA metabolism and their implications for gut health and disease status are discussed. This work was funded by Science Foundation Ireland (SFI) to APC Microbiome Institute; Grant Number SFI/12/RC/2273.
Keywords: Bile, Microbes, Disease, Microbiota, Probiotic
Joyce S. (2016). Bile alt metabolism in the gut: Lessons from the microbiota.
Conference Proceedings of IPC2016. Paper presented at the International Scientific Conference on Probiotics and Prebiotics, Budapest (p. 34.). IPC2016