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Yasuhiro Koga

Yasuhiro Koga

Professor and Head, Laboratory for Infectious Diseases, Tokai University School of Medicine,
President, Japanese Society for Probiotic Science, Associate Editor, International Journal of Probiotics and Prebiotics, Japan

Short Biography
Prof. Koga is one of the leading scientists in the medical probiotic/prebiotic science and also an opinion leader in the field of probiotics/prebiotics industries in Japan. He graduated Faculty of Medicine, Kyushu University, one of the major medical schools in Japan, in 1978, got MD and then worked as a clinician for several years. After that he went to Kyushu University Graduate School and got PhD in the field of immunology in 1984.  Since 1993, he has been appointed to Professor and Chairperson, Laboratory for Infectious Diseases, Tokai University School of Medicine. He has founded Japanese Society for Probiotic Science and taken the president of it since 1998. JSPS has become a scientific partner of International Scientific Conference on Probiotics and Prebiotics since 2010.  

Current research: 
He has been mainly doing research in the medical field of probiotics/prebiotics so far. Introduction of probiotics in the eradication therapy of Helicobacter pylori (the pathogenic bacterium causing gastric ulcer and cancer, Gut 41; 49: 1997), demonstration of the role of intestinal microbiota in the pathophysiology of allergy (J. Immunol. 159; 1739: 1997), establishment of the concept of “brain-gut axis” (J. Physiol. 558.1; 263: 2004) and finding of a prebiotic oligosaccharide capable of activating butyrate-producing bacteria in the intestine (Pediatr. Res. 2016. doi:10.1038/pr.2016.167) may be the major scholarly achievements of him in the science of probiotics/prebiotics.


1. Sudo, N., Tanaka, K., Koga, Y., Okumura, Y., Kubo, C. and Nomoto, K. 1996. Extracellular ATP activates mast cells via a mechanism that is different from the activation induced by the cross-linking of Fc receptors. J. Immunol. 156: 3970-3979.

2.Mori, T., Ando, K., Tanaka, K., Ikeda, Y., and Koga, Y. 1997. Fas-mediated apoptosis of the hematopoietic progenitor cells in mice infected with murine cytomegalovirus. Blood 89: 3565-3573.

3. Kabir, A.M.A., Aiba, Y., Takagi, A., Kamiya, S., Miwa, T. and Koga, Y. 1997. Prevention of Helicobacter pylori infection by  Lactobacilli in a gnotobiotic model. Gut 41: 49 55.

4. Sudo, N., Sawamura, S., Tanaka, K., Aiba, Y., Kubo, C. and Koga, Y.  1997. The requirement of intestinal bacterial flora for the development of IgE production system fully susceptible to oral tolerance induction. J. Immunol. 159: 1739-1745.

5. Tanaka, K., Nakazawa,H., Okada, K., Umezawa, K., Fukuyama, N. and Koga, Y. 1997. Nitric oxide mediates murine cytomegalovirus-associated pneumonitis in lungs that are free of the virus. J. Clin. Invest. 100: 1822-1830.

6.Kohda, K., Tanaka, K., Aiba, Y., Yasuda, M., Miwa, T. and Koga, Y. 1999. The role of apoptosis induced by Helicobacter pylori infection in  the development of duodenal ulcer. Gut 44: 456-462. 

7. Noda, S., Tanaka, K., Sawamura, S., Sasaki, M., Matsumoto, T., Mikami, K., and Koga, Y. 2001. The role of nitric oxide synthase type 2 in acute infection with murine cytomegalovirus. J. Immunol. 166:3533-3541.

8. Sudo N., Chida Y., Aiba Y., Sonoda J., Oyama N., Yu X-N., Kubo C., and Koga Y. 2004. Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice. J. Physiol. 558. 1 : 263-275.

9. Takahashi H., Nakano Y., Matsuoka T., Kumaki N., Asami Y., and Koga Y. 2011. Role of indigenous Lactobacilli in gastrin-mediated acid production in the mouse stomach. Applied and Environmental Microbiology. 77: 6964-6971.

10.  Sadahiro S., Suzuki T., Tanaka A., Okada K., Kamata H., Ozaki T., and Koga Y. 2014. Comparison between oral antibiotics and probiotics as bowel preparation for elective colon cancer surgery to prevent infection: Prospective randomized trial. Surgery 155: 493-503.