MODULATION OF THE GUT MICROBIOTA USING BACTERIOCIN-PRODUCING STRAINS
Teagasc Food Research Centre, Ireland
As the scientific community continues to develop an ever-greater understanding of the composition and function of the human gut microbiota, and the role of specific microbial populations in health and disease, attention will turn to the tools that are at our disposal with respect to altering these microbes in a beneficial way. Bacteriocins have the potential to make an important contribution in this regard.
We have employed a variety of approaches to identify novel bacteriocin-producing probiotics. The ability of these strains to impact on gut microbes can be assessed in a variety of ways. This includes antimicrobial assays, the use of in vitro model gut communities and in vivo studies. Studies of the impact on gut communities have been facilitated through the use of DNA sequencing and bioinformatics to get an accurate insight into changes to the gut microbiota.
A number of bacteriocin-producing probiotics have now been shown to be capable of modulating the gut microbiota in a variety of different ways. These will be reviewed in this presentation.
It is clear that bacteriocin-producing probiotics can have an important role to play as gut microbiota modulators.
Probiotics, Bacteriocin, Gut, Modulation, Microbiota
Cotter P. (2017). Modulation of the gut microbiota using bacteriocin-producing strains.
Conference Proceedings of IPC2017. Paper presented at the International Scientific Conference on Probiotics and Prebiotics, Budapest (p. 23.). IPC2017