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Patrice Cani

Patrice Cani IPC

Affiliation:
PhD, Senior Research Associate FRS-FNRS, Louvain Drug Research Institute, Metabolism and Nutrition, WELBIO, Walloon Excellence in Life sciences and BIOtechnology, NeuroMicrobiota lab, European Associated Laboratory (INSERM/UCL), Brussels, BELGIUM

Short Biography
Prof. Patrice D. Cani is senior researcher from FRS-FNRS, Université Catholique de Louvain, WELBIO, Brussels, Belgium. He is co-director of the European Associated Laboratory: “NeuroMicrobiota” (INSERM, Toulouse, France/UCL). He is dietitian, earned a M.Sc. in Human Nutrition, a M.Sc. in Health Sciences and a PhD in Biomedical Sciences with a specialization in physiology, metabolism and nutrition (2005). Dr. Cani is recipient of prestigious grants: ERC Starting Grant 2013 (ENIGMO), PoC ERC grant 2016 (Microbes4U). He is laureate of the prize “Baillet Latour Grant for Medical Research 2015”, the International Prize of Physiology Lucien Dautrebande (2016), the Belgian Endocrine Society Lecture Award (2017). He is recipient of the Chaire Bauchau 2016 and the Chaire Francqui 2017. He is member of the Royal Academy of Medicine of Belgium, the Royal Belgian Academy of Sciences, founding member of the Belgian Nutrition Society and member of several international associations. He is author/co-author of around 200 scientific research publications, reviews and book chapters, (h-index: 63; citations >16700; in Oct 2017), His motto is : “In Gut We Trust”. 

Current research: 
His main research interests are the investigation of interactions between the gut microbiota, the host and specific biological systems such as the endocannabinoid system and the innate immune system in the context of obesity, type 2 diabetes, cardiometabolic disorders and metabolic inflammation. In 2007, he published the discovery of the concept of metabolic endotoxemia, and more recently, he discovered the beneficial role of the bacteria Akkermansia muciniphila on obesity and cardiometabolic risk factors (published in PNAS 2013 and Nature Medicine 2017).


Publications:  

  1. Plovier H, Everard A, Druart C, Depommier C, Van Hul M, Geurts L, Chilloux J, Ottman N, Duparc T, Lichtenstein L, Myridakis A, Delzenne NM, Klievink J, Bhattacharjee A, van der Ark KCH, Aalvink S, Martinez LO, Dumas ME, Maiter D, Loumaye A, Hermans MP, Thissen JP, Belzer C, de Vos WM, Cani PD.
    A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice.
    Nature Medicine 2017, 23:107-113
  2. Duparc T, Plovier H, Marrachelli VG, Van Hul M, Essaghir A, Ståhlman M, Matamoros S, Geurts L, Pardo-Tendero MM, Druart C, Delzenne NM, Demoulin JB, van der Merwe SW, van Pelt J, Bäckhed F, Monleon D, Everard A, Cani PD.
    Hepatocyte MyD88 affects bile acids, gut microbiota and metabolome contributing to regulate glucose and lipid metabolism.  
    Gut. 2017, 66:620-632
  3. Cani PD. 
    Gut microbiota - at the intersection of everything?
    Nature Reviews Gastroenterol Hepatol, 2017, 14:321-322. 
  4. Geurts L, Everard A*, Van Hul M*, Essaghir A, Duparc T, Matamoros S, Plovier H, Castel J, Denis RGP, Bergiers M, Druart C, Alhouayek M, Delzenne NM, Muccioli GG, Demoulin JB, Luquet S, Cani PD. 
    Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota  
    Nature Communications. 2015, 6:6495
  5. Everard A, Geurts L, Caesar R, Van Hul M, Matamoros M, Duparc T, Denis RGP, Cochez P, Pierard P, Castel J, Bindels LB, Plovier H , Robine R, Muccioli GG, Renauld JC, Dumoutier L, Delzenne NM, Luquet S, Bäckhed F, Cani PD 
    Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status

    Nature Communications. 2014, 5;5:5648  
  6. Everard A, Belzer C, Geurts L, Ouwerkerk JP, Druart C, Bindels LB, Guiot Y, Derrien M, Muccioli GG, Delzenne NM, de Vos WM, Cani PD. 
    Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

    Proc Natl Acad Sci U S A. 2013, 110, 9066-71
  7. Fournel A, Drougard A, Duparc T, Marlin A, Brierley SM, Castro J, Le-Gonidec S, Masri B, Colom A, Lucas A, Rousset P, Cenac N, Vergnolle N, Valet P, Cani PD*, Knauf C*
    Apelin targets gut contraction to control glucose metabolism via the brain
    Gut, 2017, 66, 258-269 
  8. Dao MC, Everard A, Aron-Wisnewsky J, Sokolovska N, Prifti E, Verger EO, Kayser BD, Levenez F, Chilloux J, Hoyles L; MICRO-Obes Consortium, Dumas ME, Rizkalla SW, Doré J, Cani PD, Clément K. 
    Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology.
    Gut. 2016, 65:426-36 22 
  9. Everard A, Lazarevic V, Gaïa N, Johansson M, Ståhlman M, Backhed F, Delzenne NM, Schrenzel J, François P, Cani PD
    Microbiome of prebiotic treated mice reveals novel targets involved in host-response during obesity and diabetes
    ISME J., 2014, 8, 2116-30
  10. Cani PD, Plovier H, Van Hul M, Geurts L, Delzenne NM, Druart C, Everard A. 
    Endocannabinoids--at the crossroads between the gut microbiota and host metabolism.
    Nature Reviews Endocrinol. 2016 Mar;12(3):133-43.