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Paul de Vos

Paul de Vos IPC


University Medical Center Groningen (UMCG), Pathology and Medical Biology, Immunoendocrinology, Groningen, The Netherlands

Short Biography

Prof. Dr. Paul de Vos graduated in 1992 from the university of Groningen as immunologist and obtained his PhD in 1996. Since 1996 he is active in several lines of research related to Diabetes and bioactive food ingredients. The de Vos-group based at the University Medical Center Groningen is multidisciplinary and composed of immunologists, microbiologists and chemists.  Research efforts go from basic knowledge of carbohydrates, microorganisms to stimulation of pattern-recognition receptors and related immunological properties of effects on microbiota. More than 200 peer-reviewed papers has published by the de Vos-group. Since 2006 the carbohydrate research also moved towards controlled release and manipulation of the mucosal immune system and molecular nutrition. Carbohydrates can interact with pattern recognition receptors or interact with the microbiota. By applying tailored-made carbohydrates or microorganisms immunological processes can be changes and disease prevented. Paul de Vos is principle investigator and projectleader in the Top Institute Food and Nutrition (TIFN) and the Carbohydrate Competence Center (CCC) and is also member of the juvenile diabetes research foundation (JDRF) funded ‘encapsulation consortium’.  





  1. Lépine AFP, de Hilster RHJ, Leemhuis H, Oudhuis L, Buwalda PL, de Vos P. Higher Chain Length Distribution in Debranched Type-3 Resistant Starches (RS3) Increases TLR Signaling and Supports Dendritic Cell Cytokine Production. Mol Nutr Food Res. 2018 Nov 9:e1801007. doi: 10.1002/mnfr.201801007. 
  2. Baars A, Oosting A, Lohuis M, Koehorst M, El Aidy S, Hugenholtz F, Smidt H, Mischke M, Boekschoten MV, Verkade HJ, Garssen J, van der Beek EM, Knol J, de Vos P, van Bergenhenegouwen J, Fransen F. Sex differences in lipid metabolism are affected by presence of the gut microbiota. Sci Rep. 2018 Sep 7;8(1):13426. doi: 10.1038/s41598-018-31695-w. 
  3. Lépine AFP, de Wit N, Oosterink E, Wichers H, Mes J, de Vos P. Lactobacillus acidophilus Attenuates Salmonella-Induced Stress of Epithelial Cells by Modulating Tight-Junction Genes and Cytokine Responses. Front Microbiol. 2018 Jul 2;9:1439. doi: 10.3389/fmicb.2018.01439.
  4. Elderman M, Hugenholtz F, Belzer C, Boekschoten M, van Beek A, de Haan B, Savelkoul H, de Vos P, Faas M. Sex and strain dependent differences in mucosal immunology and microbiota composition in mice. Biol Sex Differ. 2018 Jun 18;9(1):26. doi: 10.1186/s13293-018-0186-6. 
  5. Lépine A, de Vos P. Synbiotic Effects of the Dietary Fiber Long-Chain Inulin and Probiotic Lactobacillus acidophilus W37 Can be Caused by Direct, Synergistic  Stimulation of Immune Toll-Like Receptors and Dendritic Cells. Mol Nutr Food Res. 2018 Jun 14:e1800251. doi: 10.1002/mnfr.201800251. 
  6. Sahasrabudhe NM, Beukema M, Tian L, Troost B, Scholte J, Bruininx E, Bruggeman G, van den Berg M, Scheurink A, Schols HA, Faas MM, de Vos P. Dietary Fiber Pectin Directly Blocks Toll-Like Receptor 2-1 and Prevents Doxorubicin-Induced Ileitis. Front Immunol. 2018 Mar 1;9:383. doi: 10.3389/fimmu.2018.00383. eCollection 2018. 
  7. Ren C, Dokter-Fokkens J, Figueroa Lozano S, Zhang Q, de Haan BJ, Zhang H, Faas MM, de Vos P. Lactic Acid Bacteria May Impact Intestinal Barrier Function by Modulating Goblet Cells. Mol Nutr Food Res. 2018 Mar;62(6):e1700572. doi: 10.1002/mnfr.201700572.
  8. Kiewiet MBG, Dekkers R, Ulfman LH, Groeneveld A, de Vos P, Faas MM. Immunomodulating protein aggregates in soy and whey hydrolysates and their resistance to digestion in an in vitro infant gastrointestinal model: new insights in the mechanism of immunomodulatory hydrolysates. Food Funct. 2018 Jan 24;9(1):604-613. doi: 10.1039/c7fo01537b. 
  9. Fransen F, van Beek AA, Borghuis T, Aidy SE, Hugenholtz F, van der Gaast-de Jongh C, Savelkoul HFJ, De Jonge MI, Boekschoten MV, Smidt H, Faas MM, de Vos P. Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice. Front Immunol. 2017 Nov 2;8:1385. doi: 10.3389/fimmu.2017.01385. eCollection 2017.
  10. He Y, Wu C, Li J, Li H, Sun Z, Zhang H, de Vos P, Pan LL, Sun J. Inulin-Type  Fructans Modulates Pancreatic-Gut Innate Immune Responses and Gut Barrier Integrity during Experimental Acute Pancreatitis in a Chain Length-Dependent Manner. Front Immunol. 2017 Sep 26;8:1209. doi: 10.3389/fimmu.2017.01209. eCollection 2017. Erratum in: Front Immunol. 2018 Apr 18;9:812.