Hiroshi Ohno

Group Director, Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Japan

Short Biography:

Group Director of the Laboratory for Intestinal Ecosystem at RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Japan.  He is also the Professor of the Division of Immunobiology, Department of Medical Life Science, Graduate School of Medical Life Science, Yokohama City University.  

Hiroshi trained as an immunologist in his Ph.D. program, and learned cell biology, especially protein trafficking in the cell at NIH.  By integrating his expertise in immunology and cell biology, he has been studying M cells, a subset of intestinal epithelial cells specialized for phagocytosis and transcytosis for taking up luminal particulate antigens such as bacteria to initiate mucosal immune responses.  He is also interested in the impact of commensal microbiota in the intestine on physiology and pathology of the host. 

 

Selected publications:

  1. Obata Y, Kimura S, Nakato G, Iizuka K, Miyagawa Y, Nakamura Y, Furusawa Y, Sugiyama M, Suzuki K, Ebisawa M, Fujimura Y, Yoshida H, Iwanaga T, Hase K, Ohno H., Epithelial-stromal Interaction Via Notch Signaling is Essential for the Full Maturation of Gut-associated Lymphoid Tissues. EMBO Rep. 2014 Dec;15(12):1297-304.
  2. Obata Y, Furusawa Y, Endo TA, Sharif J, Takahashi D, Atarashi K, Nakayama M, Onawa S, Fujimura Y, Takahashi M, Ikawa T, Otsubo T, Kawamura YI, Dohi T, Tajima S, Masumoto H, Ohara O, Honda K, Hori S, Ohno H, Koseki H, Hase K., The Epigenetic Regulator Uhrf1 Facilitates the Proliferation and Maturation of Colonic Regulatory T Cells. Nat Immunol. 2014 Jun;15(6):571-9
  3. Furusawa Y, Obata Y, Fukuda S, Endo TA, Nakato G, Takahashi D, Nakanishi Y, Uetake C, Kato K, Kato T, Takahashi M, Fukuda NN, Murakami S, Miyauchi E, Hino S, Atarashi K, Onawa S, Fujimura Y, Lockett T10, Clarke JM, Topping DL, Tomita M, Hori S, Ohara O, Morita T, Koseki H, Kikuchi J, Honda K, Hase K, Ohno H., Commensal Microbe-derived Butyrate Induces the Differentiation of Colonic Regulatory T Cells. Nature. 2013 Dec 19;504(7480):446-50.
  4. Atarashi K, Tanoue T, Oshima K, Suda W, Nagano Y, Nishikawa H, Fukuda S, Saito T, Narushima S, Hase K, Kim S, Fritz JV, Wilmes P, Ueha S, Matsushima K, Ohno H, Olle B, Sakaguchi S, Taniguchi T, Morita H, Hattori M, Honda K., Treg Induction by a Rationally Selected Mixture of Clostridia Strains from the Human Microbiota. Nature. 2013 Aug 8;500(7461):232-6.
  5. Okada T, Fukuda S, Hase K, Nishiumi S, Izumi Y, Yoshida M, Hagiwara T, Kawashima R, Yamazaki M, Oshio T, Otsubo T, Inagaki-Ohara K, Kakimoto K, Higuchi K, Kawamura Y, Ohno H, Dohi T., Microbiota-derived Lactate Accelerates Colon Epithelial Cell Turnover in Starvation-refed Mice. Nat Commun. 2013;4:1654.
  6. Kanaya T, Hase K, Takahashi D, Fukuda S, Hoshino K, Sasaki I, Hemmi H, Knoop KA, Kumar N, Sato M, Katsuno T, Yokosuka O, Toyooka K, Nakai K, Sakamoto A, Kitahara Y, Jinnohara T, McSorley SJ, Kaisho T, Williams IR, Ohno H.,The Ets Transcription Factor Spi-B is Essential for the Differentiation of Intestinal Microfold Cells. Nat Immunol. 2012 Jun 17;13(8):729-36
  7. Obata Y, Takahashi D, Ebisawa M, Kakiguchi K, Yonemura S, Jinnohara T, Kanaya T, Fujimura Y, Ohmae M, Hase K, Ohno H., Epithelial Cell-intrinsic Notch Signaling Plays an Essential Role in the Maintenance of Gut Immune Homeostasis. J Immunol. 2012 Mar 1;188(5):2427-36.
  8. Fukuda S, Toh H, Hase K, Oshima K, Nakanishi Y, Yoshimura K, Tobe T, Clarke JM, Topping DL, Suzuki T, Taylor TD, Itoh K, Kikuchi J, Morita H, Hattori M, Ohno H., Bifidobacteria Can Protect from Enteropathogenic Infection Through Production of Acetate. Nature. 2011 Jan 27;469(7331):543-7. Doi: 10.1038/Nature09646.
  9. Hase K, Kawano K, Nochi T, Pontes GS, Fukuda S, Ebisawa M, Kadokura K, Tobe T, Fujimura Y, Kawano S, Yabashi A, Waguri S, Nakato G, Kimura S, Murakami T, Iimura M, Hamura K, Fukuoka S, Lowe AW, Itoh K, Kiyono H, Ohno H., Uptake Through Glycoprotein 2 of FimH(+) Bacteria By M Cells Initiates Mucosal Immune Response. Nature. 2009 Nov 12;462(7270):226-30.
  10. Shima H, Watanabe T, Fukuda S, Fukuoka S, Ohara O, Ohno H., A Novel Mucosal Vaccine Targeting Peyer's Patch M Cells Induces Protective Antigen-specific IgA Responses. Int Immunol. 2014 Nov;26(11):619-25.
  11. Kato T, Fukuda S, Fujiwara A, Suda W, Hattori M, Kikuchi J, Ohno H. Multiple Omics Uncovers Host-gut Microbial Mutualism During Prebiotic Fructooligosaccharide Supplementation. DNA Res. 2014 Oct;21(5):469-80.