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Kathleen McCoy

Current affiliation: Cumming School of Medicine, University of Calgary, Alberta, Canada

Short Biography (5-10 sentences):
Prof. McCoy obtained her PhD in Immunology from the Malaghan Institute of Medical Research, Otago University, Wellington, New Zealand. She performed her postdoctoral studies and was a junior group leader at the Institute of Experimental Immunology in Zürich, Switzerland. In 2006 she joined McMaster University as an Assistant Professor where she held a Canada Research Chair in Mucosal Immunology. From 2010 – 2016 Kathy McCoy was an Assistant Professor in Mucosal Immunology in the Department of Clinical Research, University of Bern in Switzerland. In Sept. 2016 she returned to Canada and is now a Professor in the Cumming School of Medicine, University of Calgary where she continues her research on host-microbial interactions with a focus on early life.

Current Research:
Prof. Kathy McCoy is interested in the dynamic interplay between the gut microbiota and the innate and adaptive immune systems. Using germ-free and gnotobiotic mouse models her research group aims to understand how exposure to intestinal microbes early in life educates and regulates the developing immune system and how this impacts on susceptibility to immune-mediated diseases such as allergy and autoimmunity. 

Recent publications:

1.       Gomez de Agüero M*, Ganal-Vonarburg SC*, Fuhrer T, Rupp S, Uchimura Y, Steinert A, Heikenwälder M, Hapfelmeier S, Sauer U, McCoy KD, Macpherson AJ. Early postnatal innate immune development driven by the maternal microbiota. Science In Press. *Equal first authors, †Equal senior authors.

2.       Zaiss MM, Rapin A, Lebon L, Dubey LK, Mosconi I, Sarter K, Piersigilli A, Menin L, Walker AW, Rougemont J, Paerewijck O, Geldhof P, McCoy KD, Macpherson AJ, Croese J, Giacomin PR, Loukas A, Junt T, Marsland BJ, Harris NL. The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation. Immunity. 2015 Nov 17;43(5):998-1010.

3.       Li H*, Limenitakis JP*, Fuhrer T, Geuking MB, Lawson MA, Wyss M, Brugiroux S, Keller I, Macpherson JA, Rupp S, Stolp B, Stein JV, Stecher B, Sauer U, McCoy KD, Macpherson AJ.  The outer mucus layer hosts a distinct intestinal microbial niche. Nat Commun. 2015 Sep 22;6:8292. *Contributed equally 

4.       Brasseit J, Althaus-Steiner E, Faderl M, Dickgreber N, Saurer L, Genitsch V, Dolowschiak T, Li H, Finke D, Hardt WD, McCoy KD, Macpherson AJ, Corazza N, Noti M, Mueller C. CD4 T cells are required for both development and maintenance of disease in a new mouse model of reversible colitis. Mucosal Immunol. 2015 Sep 16.

5.        Macpherson AJ, Köller Y, McCoy KDThe bilateral responsiveness between intestinal microbes and IgA. Trends Immunol. 2015 Aug;36(8):460-70. 

6.       Erny D, Hrabě de Angelis AL, Jaitin D, Wieghofer P, Staszewski O, David E, Keren-Shaul H, Mahlakoiv T, Jakobshagen K, Buch T, Schwierzeck V, Utermöhlen O, Chun E, Garrett WS, McCoy KD, Diefenbach A, Staeheli P, Stecher B, Amit I, Prinz M. Host microbiota constantly control maturation and function of microglia in the CNS. Nat Neurosci. 2015 Jul;18(7):965-77. 

7.       Roediger B, Kyle R, Tay SS, Mitchell AJ, Bolton HA, Guy TV, Tan SY, Forbes-Blom E, Tong PL, Köller Y, Shklovskaya E, Iwashima M, McCoy KD, Le Gros G, Fazekas de St Groth B, Weninger W. IL-2 is a critical regulator of group 2 innate lymphoid cell function during pulmonary inflammation. J Allergy Clin Immunol. 2015 May 26. 

8.       Mager LF, Riether C, Schürch CM, Banz Y, Wasmer MH, Stuber R, Theocharides AP, Li X, Xia Y, Saito H, Nakae S, Baerlocher GM, Manz MG, McCoy KD, Macpherson AJ, Ochsenbein AF, Beutler B, Krebs P. IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms. J Clin Invest. 2015 Jul 1;125(7):2579-91.

9.       McCoy KD, Köller Y. New developments providing mechanistic insight into the impact of the microbiota on allergic disease. Clin Immunol. 2015 May 16.

10.    Macpherson AJ, McCoy KDStandardised animal models of host microbial mutualism. Mucosal Immunol. 2015 May;8(3):476-86.

11.    Bornancin F, Renner F, Touil R, Sic H, Kolb Y, Touil-Allaoui I, Rush JS, Smith PA, Bigaud M, Junker-Walker U, Burkhart C, Dawson J, Niwa S, Katopodis A, Nuesslein-Hildesheim B, Weckbecker G, Zenke G, Kinzel B, Traggiai E, Brenner D, Brüstle A, St Paul M, Zamurovic N, McCoy KD, Rolink A, Régnier CH, Mak TW, Ohashi PS, Patel DD, Calzascia T. Deficiency of MALT1 paracaspase activity results in unbalanced regulatory and effector T and B cell responses leading to multiorgan inflammation. J Immunol. 2015 Apr 15;194(8):3723-34.

12.    Moghadamrad S, McCoy KD, Geuking MB, Sägesser H, Kirundi J, Macpherson AJ, De Gottardi A. Attenuated portal hypertension in germ-free mice: Function of bacterial flora on the development of mesenteric lymphatic and blood vessels. Hepatology. 2015 May;61(5):1685-95.

13.    Proietti M, Cornacchione V, Rezzonico Jost T, Romagnani A, Faliti CE, Perruzza L, Rigoni R, Radaelli E, Caprioli F, Preziuso S, Brannetti B, Thelen M, McCoy KD, Slack E, Traggiai E, Grassi F. TP-gated ionotropic P2X7 receptor controls follicular T helper cell numbers in Peyer's patches to promote host-microbiota mutualism. Immunity 2014 Nov 20;41(5):789-801. 

14.    Balmer ML, Schürch CM, Saito, Y, Geuking MB, Hai Li, Ceunca M, Kovtonyuk, LV, McCoy KD, Hapfelmeier S, Ochsenbein AF, Manz MG, Slack E, Macpherson AJ. Microbiota-derived compounds drive steady-state granulopoesis via MyD88/TICAM signaling. Journal of Immunology 2014 Nov 15;193(10):5273-83

15.    Stefka AT, Feehley T, Tripathi P, Qiu J, McCoy K, Mazmanian SK, Tjota MY, Seo G-Y, Cao S, Theriault BR, Antonopoulos DA, Zhou L, Chang EB, Fu Y-X, and Nagler CR. Commensal bacteria protect against food allergen sensitization. PNAS 2014 Nov 13;14(5):559-70.  (Citations 21; IF 9.80)

16.    Chu DK, Jimenez-Saiz R, Verschoor CP, Walker TD, Goncharova S, Llop-Guevara A, Shen P, Gordon ME, Barra NG, Bassett JD, Kong J, Fattouh R, McCoy KD, Bowdish DM, Erjefält JS, Pabst O, Humbles AA, Kolbeck R, Waserman S, Jordana M. Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo. J. Exp Med. 2014 Jul 28;211(8):1657-72.

17.    Gollwitzer ES, Saglani S, Trompette A, Yadava K, Sherburn R, McCoy KD, Nicod LP, Lloyd CM, Marsland BJ. Lung microbiota promotes tolerance to allergens in neonates via PD-L1. Nat Med. 2014 Jun;20(6):642-7. 

18.    Geuking MB, Köller Y, Rupp S, and McCoy KD. The interplay between the gut microbiota and the immune system. Gut Microbes 2014 Jun 12;5(3).

19.    Balmer MB, Slack E, de Gottardi A, Lawson MAE, Hapfelmeier S, Miele L, Grieco A, Van Vlierberghe H, Fahrner R, Patuto N, Bernsmeier C, Ronchi F, Wyss M, Stroka D, Dickgreber N, Heim MH, McCoy KD, and Macpherson AJ. The Liver May Act as a Firewall Mediating Mutualism Between the Host and Its gut Commensal Microbiota. Sci Transl Med. 2014 May 21;6(237):237ra66.

20.    Lécuyer E, Rakotobe S, Lengliné-Garnier H, Lebreton C, Picard M, Juste C, Fritzen R, Eberl G, McCoy KD, Macpherson AJ, Reynaud CA, Cerf-Bensussan N, Gaboriau-Routhiau V. Segmented filamentous bacterium uses secondary and tertiary lymphoid tissues to induce gut IgA and specific T helper 17 cell responses. Immunity 2014 Apr 17;40(4):608-20.  

21.    Cahenzli J, Köller Y, Wyss M, Geuking MB, and McCoy KD. Intestinal microbial diversity during early-life colonization shapes long-term IgE levels. Cell Host Microbe 2013 Nov 13;14(5):559-70.