Norbert Sprenger

Affiliation: Expert and Senior Research Scientist, Nutrition and Health Research, Nestlé Research Center, Nestec S.A. Lausanne, Switzerland

 

Short Biography:

Norbert Sprenger obtained his PhD from the University of Basel, Switzerland and Post-doctoral Fellowships at the University of Zurich, Switzerland and Stanford University, California. Since 2000 he works as a Senior Research Scientist at the Nestlé Research Center, Switzerland.
He has published 33 articles, 28 international patents, H index: 22.


Current Research: 
Biology of milk oligosaccharides for infant nutrition and health. Effects on host microbe interaction and protection from infection.

 

Publications:

  1.  

    FUT2-dependent breast milk oligosaccharides and allergy at 2 and 5 years of age in infants with high hereditary allergy risk. Sprenger N, Odenwald H, Kukkonen AK, Kuitunen M, Savilahti E, Kunz C. Eur J Nutr. 2016 Feb 24.

  2. Glycoprofiling with micro-arrays of glycoconjugates and lectins. Angeloni S, Ridet JL, Kusy N, Gao H, Crevoisier F, Guinchard S, Kochhar S, Sigrist H, Sprenger N. Glycobiology. 2005 Jan;15(1):31-41.

  3. Biochemical characterization of rat intestine development using high-resolution magic-angle-spinning 1H NMR spectroscopy and multivariate data analysis. Wang Y, Tang H, Holmes E, Lindon JC, Turini ME, Sprenger N, Bergonzelli G, Fay LB, Kochhar S, Nicholson JK. J Proteome Res. 2005 Jul-Aug;4(4):1324-9.

  4. Glycans on secretory component participate in innate protection against mucosal pathogens. Perrier C, Sprenger N, Corthésy B. J Biol Chem. 2006 May 19;281(20):14280-7.

  5. Experimental metabonomic model of dietary variation and stress interactions. Wang Y, Holmes E, Tang H, Lindon JC, Sprenger N, Turini ME, Bergonzelli G, Fay LB, Kochhar S, Nicholson JK. J Proteome Res. 2006 Jul;5(7):1535-42.

  6. Effects of probiotic Lactobacillus paracasei treatment on the host gut tissue metabolic profiles probed via magic-angle-spinning NMR spectroscopy. Martin FP, Wang Y, Sprenger N, Holmes E, Lindon JC, Kochhar S, Nicholson JK. J Proteome Res. 2007 Apr;6(4):1471-81.

  7. A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model. Martin FP, Dumas ME, Wang Y, Legido-Quigley C, Yap IK, Tang H, Zirah S, Murphy GM, Cloarec O, Lindon JC, Sprenger N, Fay LB, Kochhar S, van Bladeren P, Holmes E, Nicholson JK. Mol Syst Biol. 2007;3:112.

  8. Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model. Martin FP, Wang Y, Sprenger N, Yap IK, Lundstedt T, Lek P, Rezzi S, Ramadan Z, van Bladeren P, Fay LB, Kochhar S, Lindon JC, Holmes E, Nicholson JK. Mol Syst Biol. 2008;4:157.

  9. Top-down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model. Martin FP, Wang Y, Sprenger N, Yap IK, Rezzi S, Ramadan Z, Peré-Trepat E, Rochat F, Cherbut C, van Bladeren P, Fay LB, Kochhar S, Lindon JC, Holmes E, Nicholson JK. Mol Syst Biol. 2008;4:205.

  10. Panorganismal gut microbiome-host metabolic crosstalk. Martin FP, Sprenger N, Yap IK, Wang Y, Bibiloni R, Rochat F, Rezzi S, Cherbut C, Kochhar S, Lindon JC, Holmes E, Nicholson JK. J Proteome Res. 2009 Apr;8(4):2090-105.

  11. Topographical variation in murine intestinal metabolic profiles in relation to microbiome speciation and functional ecological activity. Martin FP, Wang Y, Yap IK, Sprenger N, Lindon JC, Rezzi S, Kochhar S, Holmes E, Nicholson JK. J Proteome Res. 2009 Jul;8(7):3464-74.

  12. Sialic acid feeding aged rats rejuvenates stimulated salivation and colon enteric neuron chemotypes. Sprenger N, Julita M, Donnicola D, Jann A. Glycobiology. 2009 Dec;19(12):1492-502.

  13. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Trompette A, Gollwitzer ES, Yadava K, Sichelstiel AK, Sprenger N, Ngom-Bru C, Blanchard C, Junt T, Nicod LP, Harris NL, Marsland BJ. Nat Med. 2014 Feb;20(2):159-66.

  14. Milk oligosaccharides over time of lactation from different dog breeds. Macias Rostami S, Bénet T, Spears J, Reynolds A, Satyaraj E, Sprenger N, Austin S. PLoS One. 2014 Jun 12;9(6):e99824.

  15. Growth and safety evaluation of infant formulae containing oligosaccharides derived from bovine milk: a randomized, double-blind, noninferiority trial. Meli F, Puccio G, Cajozzo C, Ricottone GL, Pecquet S, Sprenger N, Steenhout P. BMC Pediatr. 2014 Dec 20;14:306.

  16. Gut microbiota analysis reveals a marked shift to bifidobacteria by a starter infant formula containing a synbiotic of bovine milk-derived oligosaccharides and Bifidobacterium animalis subsp. lactis CNCM I-3446. Simeoni U, Berger B, Junick J, Blaut M, Pecquet S, Rezzonico E, Grathwohl D, Sprenger N, Brüssow H; Study team, Szajewska H. Environ Microbiol. 2015 Dec 2. doi: 10.1111/1462-2920.13144.