Koen Venema

Remco Kort IPC

Presentation title: How interindividual microbiota composition complicates outcomes of functional food trials --- or does it?

Biography: Koen Venema is i) Professor at University Maastricht - campus Venlo, ii) founder and CEO of Beneficial Microbes® Consultancy, iii) founder and CEO of Beneficial Bugs BV, iv) CMO of InnerBuddies, v) organizer of the Beneficial Microbes Conference-series, and vi) editor-in-chief of Beneficial Microbes.
He received his PhD from the University of Groningen, on the antimicrobial activity of bacteriocins produced by lactic acid bacteria (LAB) in 1995. He pursued the health-beneficial activity of these microbes as a Post-Doc at North Carolina State University, Raleigh, USA, where he studied the potential of LAB to function as carrier for vaccines. Thereafter, he was employed by the Dutch Organization for Applied Scientific Research (TNO) for > 15 years, where he used the sophisticated, dynamic, computer-controlled in vitro models of the gastro-intestinal tract (nick-named TIM) to study the effect of functional foods
and drugs on the colonic microbiota. Since Sept. 01, 2014 he runs a newly established research group at Maastricht University – campus Venlo at the Centre for Healthy Eating & Food Innovation, where the focus is on the effects of dietary components on the composition and activity of the gut microbiota, and through this on the (digestive) health of the host, with a chair in Gut Microbiology since Nov 2015. Here, he continues to use the TNO in vitro models.


Recent publications

1: Canfora EE, Hermes GDA, Müller M, Bastings J, Vaughan EE, van Den Berg MA,
Holst JJ, Venema K, Zoetendal EG, Blaak EE. Fiber mixture-specific effect on
distal colonic fermentation and metabolic health in lean but not in prediabetic
men. Gut Microbes. 2022 Jan-Dec;14(1):2009297. doi:
10.1080/19490976.2021.2009297. PMID: 34923911; PMCID: PMC8726743.

2: Sost MM, Ahles S, Verhoeven J, Verbruggen S, Stevens Y, Venema K. A Citrus
Fruit Extract High in Polyphenols Beneficially Modulates the Gut Microbiota of
Healthy Human Volunteers in a Validated In Vitro Model of the Colon. Nutrients.
2021 Nov 1;13(11):3915. doi: 10.3390/nu13113915. PMID: 34836169; PMCID:

3: Oost MJ, Velkers FC, Kraneveld AD, Venema K. Development of the in
Cecal Chicken ALIMEntary tRact mOdel-2 to Study Microbiota Composition
and Function. Front Microbiol. 2021 Oct 11;12:726447. doi:
10.3389/fmicb.2021.726447. PMID: 34707583; PMCID: PMC8542841.

4: Seal CJ, Courtin CM, Venema K, de Vries J. Health benefits of whole grain:
effects on dietary carbohydrate quality, the gut microbiome, and consequences of
processing. Compr Rev Food Sci Food Saf. 2021 May;20(3):2742-2768. doi:
10.1111/1541-4337.12728. Epub 2021 Mar 7. PMID: 33682356.

5: Sáyago-Ayerdi SG, Venema K, Tabernero M, Sarriá B, Bravo LL, Mateos R.
Bioconversion by gut microbiota of predigested mango (Mangifera indica L)
'Ataulfo' peel polyphenols assessed in a dynamic (TIM-2) in vitro model of the
human colon. Food Res Int. 2021 Jan;139:109963. doi:
10.1016/j.foodres.2020.109963. Epub 2020 Dec 8. PMID: 33509513.

6: Surono IS, Widiyanti D, Kusumo PD, Venema K. Gut microbiota profile of
Indonesian stunted children and children with normal nutritional status. PLoS
One. 2021 Jan 26;16(1):e0245399. doi: 10.1371/journal.pone.0245399. PMID:
33497390; PMCID: PMC7837488.

7: Long C, Venema K. Pretreatment of Rapeseed Meal Increases Its Recalcitrant
Fiber Fermentation and Alters the Microbial Community in an in vitro
Model of Swine Large Intestine. Front Microbiol. 2020 Nov 19;11:588264. doi:
10.3389/fmicb.2020.588264. PMID: 33329463; PMCID: PMC7711092.

8: Míguez B , Vila C , Venema K , Parajó JC , Alonso JL . Prebiotic effects of
pectooligosaccharides obtained from lemon peel on the microbiota from elderly
donors using an in vitro continuous colon model (TIM-2). Food Funct. 2020
Nov 18;11(11):9984-9999. doi: 10.1039/d0fo01848a. PMID: 33119011.

9: Ayoub Moubareck C, Lootah M, Tahlak M, Venema K. Profiles of Human Milk
Oligosaccharides and Their Relations to the Milk Microbiota of Breastfeeding
Mothers in Dubai. Nutrients. 2020 Jun 9;12(6):1727. doi: 10.3390/nu12061727.
PMID: 32526930; PMCID: PMC7353065.

10: Larsen N, Bussolo de Souza C, Krych L, Barbosa Cahú T, Wiese M, Kot W,
Hansen KM, Blennow A, Venema K, Jespersen L. Potential of Pectins to
Beneficially Modulate the Gut Microbiota Depends on Their Structural Properties.
Front Microbiol. 2019 Feb 15;10:223. doi: 10.3389/fmicb.2019.00223. PMID:
30828323; PMCID: PMC6384267.