Michiel Kleerebezem

Michiel Kleerebezem IPC

Prof. Dr., Wageningen UR, Animal Sciences, Host Microbiome Interactomics

Michiel Kleerebezem obtained his PhD in Molecular Microbiology at the University of Utrecht in 1995. Since then he has been employed at NIZO food research. From 1998, part of his time has been dedicated to research performed within TI Food & Nutrition where he was appointed as scientific director in 2011. In 2007 he was appointed as special professor at the Laboratory for Microbiology at Wageningen University, and has now been appointed as a personal professor at the Host Microbe Interactomics Group at the same university. 
His expertise centers around the molecular biology and physiology of bacteria, with a special focus on lactic acid bacteria, probiotics, and the intestinal microbiota. He is strongly involved in the genomics driven work related to understanding the molecular mechanisms of environmental adaptation in Lactobacillus plantarum and Lactococcus lactis, focusing on adaptation to the conditions encountered in the oro-gastrointestinal tract and conditions encountered during (industrial) dairy fermentation, respectively. In recent years he has expanded his field to the (post-genomic) molecular analysis of the mechanisms of communication between intestinal bacteria and the host mucosa.  Michiel Kleerebezem has (co-) authored more than 200 peer-reviewed publications and is inventor on more than 25 patent applications.

Recent publications:

  1. Complete Genome Sequence of Streptococcus salivarius HSISS4, a Human Commensal Bacterium Highly Prevalent in the Digestive Tract.
    Mignolet J, Fontaine L, Kleerebezem M, Hols P.
    Genome Announc. 2016 Feb 4;4(1). pii: e01637-15. doi: 10.1128/genomeA.01637-15.
  2. Functional Profiling of Unfamiliar Microbial Communities Using a Validated De Novo Assembly Metatranscriptome Pipeline.
    Davids M, Hugenholtz F, Martins Dos Santos V, Smidt H, Kleerebezem M, Schaap PJ.
    PLoS One. 2016 Jan 12;11(1):e0146423. doi: 10.1371/journal.pone.0146423. eCollection 2016.
  3. Characterisation of the transcriptional regulation of the tarIJKL-locus involved in ribitol-containing wall teichoic acid biosynthesis in Lactobacillus plantarum.
    Tomita S, Lee IC, van Swam II, Boeren S, Vervoort J, Bron PA, Kleerebezem M.
    Microbiology. 2015 Dec 17. doi: 10.1099/mic.0.000229. [Epub ahead of print]
  4. Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota.
    Forslund K, Hildebrand F, Nielsen T, Falony G, Le Chatelier E, Sunagawa S, Prifti E, Vieira-Silva S, Gudmundsdottir V, Krogh Pedersen H, Arumugam M, Kristiansen K, Voigt AY, Vestergaard H, Hercog R, Igor Costea P, Kultima JR, Li J, Jørgensen T, Levenez F, Dore J; MetaHIT consortium, Nielsen HB, Brunak S, Raes J, Hansen T, Wang J, Ehrlich SD, Bork P, Pedersen O.
    Nature. 2015 Dec 10;528(7581):262-6. doi: 10.1038/nature15766. Epub 2015 Dec 2.
  5. Resequencing of the Lactobacillus plantarum Strain WJL Genome.
    Martino ME, Bayjanov JR, Joncour P, Hughes S, Gillet B, Kleerebezem M, Siezen R, van Hijum SA, Leulier F.
    Genome Announc. 2015 Nov 25;3(6). pii: e01382-15. doi: 10.1128/genomeA.01382-15.
  6. Nearly Complete Genome Sequence of Lactobacillus plantarum Strain NIZO2877.
    Martino ME, Bayjanov JR, Joncour P, Hughes S, Gillet B, Kleerebezem M, Siezen R, van Hijum SA, Leulier F.
    Genome Announc. 2015 Nov 25;3(6). pii: e01370-15. doi: 10.1128/genomeA.01370-15.
  7. Gut microbiota facilitates dietary heme-induced epithelial hyperproliferation by opening the mucus barrier in colon.
    Ijssennagger N, Belzer C, Hooiveld GJ, Dekker J, van Mil SW, Müller M, Kleerebezem M, van der Meer R.
    Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):10038-43. doi: 10.1073/pnas.1507645112. Epub 2015 Jul 27.
  8. Towards microbial fermentation metabolites as markers for health benefits of prebiotics.
    Verbeke KA, Boobis AR, Chiodini A, Edwards CA, Franck A, Kleerebezem M, Nauta A, Raes J, van Tol EA, Tuohy KM.
    Nutr Res Rev. 2015 Jun;28(1):42-66. doi: 10.1017/S0954422415000037.
  9. Mining microbial metatranscriptomes for expression of antibiotic resistance genes under natural conditions.
    Versluis D, D'Andrea MM, Ramiro Garcia J, Leimena MM, Hugenholtz F, Zhang J, Öztürk B, Nylund L, Sipkema D, van Schaik W, de Vos WM, Kleerebezem M, Smidt H, van Passel MW.
    Sci Rep. 2015 Jul 8;5:11981. doi: 10.1038/srep11981.
  10. Correlation of Lactobacillus rhamnosus Genotypes and Carbohydrate Utilization Signatures Determined by Phenotype Profiling.
    Ceapa C, Lambert J, van Limpt K, Wels M, Smokvina T, Knol J, Kleerebezem M.
    Appl Environ Microbiol. 2015 Aug 15;81(16):5458-70. doi: 10.1128/AEM.00851-15. Epub 2015 Jun 5.
  11. Physiological and Transcriptional Responses of Different Industrial Microbes at Near-Zero Specific Growth Rates.
    Ercan O, Bisschops MM, Overkamp W, Jørgensen TR, Ram AF, Smid EJ, Pronk JT, Kuipers OP, Daran-Lapujade P, Kleerebezem M.
    Appl Environ Microbiol. 2015 Sep 1;81(17):5662-70. doi: 10.1128/AEM.00944-15. Epub 2015 Jun 5. Review.
  12. Comparison of the effects of five dietary fibers on mucosal transcriptional profiles, and luminal microbiota composition and SCFA concentrations in murine colon.
    Lange K, Hugenholtz F, Jonathan MC, Schols HA, Kleerebezem M, Smidt H, Müller M, Hooiveld GJ.
    Mol Nutr Food Res. 2015 Aug;59(8):1590-602. doi: 10.1002/mnfr.201400597. Epub 2015 Jun 17.