Manuela Sailer

Affiliation: BENEO-Institute, Manager Nutrition Science, BENEO GmbH, Mannheim, Germany

Short Biography:

Manuela Sailer has a MSc in Nutrition Science from the University of Giessen, Germany and obtained a PhD (Dr. rer. nat.) from the Technical University of Munich (2013). She was member of the Research Training Group “Interface functions of the intestine between luminal factors and host signals” for PhD fellows.  
In 2013 she joined BENEO. At BENEO-Institute she works as a Manager Nutrition Science.

Current Research: 

Her research activities are on the nutritional benefits of BENEO’s functional fiber ingredients and her interest is in particular on the effect of inulin-type fructans on gut health.


    1. Loss of function mutation of the Slc38a3 glutamine transporter reveals its critical role for amino acid metabolism in the liver, brain, and kidney. Chan K, Busque SM, Sailer M, Stoeger C, Bröer S, Daniel H, Rubio-Aliaga I, Wagner CA. Pflugers Arch. 2016 Feb;468(2):213-27. doi: 10.1007/s00424-015-1742-0. Epub 2015 Oct 21.
    2. Methyl-donor supplementation in obese mice prevents the progression of NAFLD, activates AMPK and decreases acyl-carnitine levels. Dahlhoff C, Worsch S, Sailer M, Hummel BA, Fiamoncini J, Uebel K, Obeid R, Scherling C, Geisel J, Bader BL, Daniel H. Mol Metab. 2014 May 20;3(5):565-80. doi: 10.1016/j.molmet.2014.04.010. eCollection 2014 Aug.
    3. Increased plasma citrulline in mice marks diet-induced obesity and may predict the development of the metabolic syndrome. Sailer M, Dahlhoff C, Giesbertz P, Eidens MK, de Wit N, Rubio-Aliaga I, Boekschoten MV, Müller M, Daniel H. PLoS One. 2013 May 14;8(5):e63950. doi: 10.1371/journal.pone.0063950. Print 2013.
    4. Hepatic methionine homeostasis is conserved in C57BL/6N mice on high-fat diet despite major changes in hepatic one-carbon metabolism. Dahlhoff C, Desmarchelier C, Sailer M, Fürst RW, Haag A, Ulbrich SE, Hummel B, Obeid R, Geisel J, Bader BL, Daniel H. PLoS One. 2013;8(3):e57387. doi: 10.1371/journal.pone.0057387. Epub 2013 Mar 5. Erratum in: PLoS One. 2013;8(10). doi:10.1371/annotation/9dd8c2df-1921-45b4-b3ba-8919f9068aea.
    5. The dynamic range of the human metabolome revealed by challenges. Krug S, Kastenmüller G, Stückler F, Rist MJ, Skurk T, Sailer M, Raffler J, Römisch-Margl W, Adamski J, Prehn C, Frank T, Engel KH, Hofmann T, Luy B, Zimmermann R, Moritz F, Schmitt-Kopplin P, Krumsiek J, Kremer W, Huber F, Oeh U, Theis FJ, Szymczak W, Hauner H, Suhre K, Daniel H. FASEB J. 2012 Jun;26(6):2607-19. doi: 10.1096/fj.11-198093. Epub 2012 Mar 16.
    6. C57Bl/6 N mice on a western diet display reduced intestinal and hepatic cholesterol levels despite a plasma hypercholesterolemia. Desmarchelier C, Dahlhoff C, Keller S, Sailer M, Jahreis G, Daniel H. BMC Genomics. 2012 Mar 6;13:84. doi: 10.1186/1471-2164-13-84.
    7. The intestinal peptide transporter PEPT1 is involved in food intake regulation in mice fed a high-protein diet. Nässl AM, Rubio-Aliaga I, Sailer M, Daniel H. PLoS One. 2011;6(10):e26407. doi: 10.1371/journal.pone.0026407. Epub 2011 Oct 21.
    8. Alterations in hepatic one-carbon metabolism and related pathways following a high-fat dietary intervention. Rubio-Aliaga I, Roos Bd, Sailer M, McLoughlin GA, Boekschoten MV, van Erk M, Bachmair EM, van Schothorst EM, Keijer J, Coort SL, Evelo C, Gibney MJ, Daniel H, Muller M, Kleemann R, Brennan L. Physiol Genomics. 2011 Apr 27;43(8):408-16. doi: 10.1152/physiolgenomics.00179.2010. Epub 2011 Feb 8. Erratum in: Physiol Genomics. 2012 May 1;44(10):593.
    9. The NuGO proof of principle study package: a collaborative research effort of the European Nutrigenomics Organisation. Baccini M, Bachmaier EM, Biggeri A, Boekschoten MV, Bouwman FG, Brennan L, Caesar R, Cinti S, Coort SL, Crosley K, Daniel H, Drevon CA, Duthie S, Eijssen L, Elliott RM, van Erk M, Evelo C, Gibney M, Heim C, Horgan GW, Johnson IT, Kelder T, Kleemann R, Kooistra T, van Iersel MP, Mariman EC, Mayer C, McLoughlin G, Müller M, Mulholland F, van Ommen B, Polley AC, Pujos-Guillot E, Rubio-Aliaga I, Roche HM, de Roos B, Sailer M, Tonini G, Williams LM, de Wit N; NuGO PPS Team. Genes Nutr. 2008 Dec;3(3-4):147-51. doi: 10.1007/s12263-008-0102-5. Epub 2008 Nov 26. No abstract available.