Emanuela Simonetti

Current affiliation:
Research Director of Kamut Enterprises of Europe, Belgium.

Short Biography:

Degree in Biology (specialization in Biotechnology).
From 2000 to 2004: researcher for private companies and International Institutes, such as the Laboratory of Molecular Oncology of Consorzio Mario Negri Sud (S. Maria Imbaro, CH, ITALY).
From 2004 to 2013: Founder and R&D Manager of a private Italian biotechnology company working in the molecular diagnostic market.
From 2014 up to now: Research Director of Kamut Enterprises of Europe (Belgium).

Current research area: assessment of the healthy properties of the ancient KAMUT® khorasan wheat

In collaboration with the Italian Universities of Bologna, Firenze, Urbino and Parma, many studies have been designed to evaluate this grain’s healthy properties, in particular, the phytochemical profile, the hypoallergenicity, the digestibility and the antioxidant and anti-inflammatory protection of KAMUT® khorasan wheat compared to modern wheat. These studies have been conducted in vitro and in vivo enrolling both healthy volunteers and patients with chronic non-infectious diseases such as cardiovascular disease, diabetes, Irritable Bowel Syndrome and Non-Celiac Gluten Sensitivity. Ongoing and future studies are on volunteers with non-alcoholic fatty liver disease, obesity and dementia.

Selected publications from the research program supported by Kamut International:

  1. Determination of phenolic compounds in modern and old varieties of durum wheat using liquid chromatography coupled with time-of-flight mass spectrometry. Dinelli G. et al. Journal of Chromatography A. 2009 Oct 23;1216(43):7229-40.
  2. Role of cereal type and processing in whole grain in vivo protection from oxidative stress. Gianotti A. et al., Frontiers in Bioscience (Landmark Ed). 2011 Jan 1;16:1609-18.
  3. Counteraction of oxidative damage in the rat liver by an ancient grain (KAMUT brand khorasan wheat). Benedetti S. et al., Nutrition. 2012 Apr;28(4):436-41.
  4. Prebiotic effect of soluble fibres from modern and old durum-type wheat varieties on Lactobacillus and Bifidobacterium strains. Marotti I. et al., Journal of the Science of Food and Agriculture. 2012 Aug 15;92(10):2133-40.
  5. Characterization of khorasan wheat (Kamut) and impact of a replacement diet on cardiovascular risk factors: cross-over dietary intervention study. Sofi F. et al., European Journal of Clinical Nutrition. 2013 Feb;67(2):190-5.
  6. Lunasin in wheat: a chemical and molecular study on its presence or absence. Dinelli G. et al., Food Chemistry 2014 May 15;151:520-5.
  7. Role of Kamut® brand khorasan wheat in the counteraction of non-celiac wheat sensitivity and oxidative damage. Carnevali A. et al., Food Research International. 2014, 63: 218–226.
  8. Effect of Triticum turgidum subsp. turanicum wheat on irritable bowel syndrome: a double-blinded randomised dietary intervention trial. Sofi F. et al., British Journal of Nutrition. 2014 Jun; 111(11): 1992-1999.
  9. Impact of Kamut® Khorasan on gut microbiota and metabolome in healthy volunteers. Taneyo Saa D. et al., Food Research International. 2014, 63: 227–232.
  10. Effects of flour storage and heat generated during milling on starch, dietary fibre and polyphenols in stoneground flours from two durum-type wheats. Di Silvestro et al., Int J Food Sci Tech. 2014, October  49,  10: 2230–2236.
  11. Agronomic traits and deoxynivalenol contamination of two tetraploid wheat species (Triticum turgidum spp. durum, Triticum turgidum spp. turanicum) grown under strictly low input conditions. Dinelli et al., Italian Journal of Agronomy 2014; 9:583.
  12. Responses of peripheral blood mononucleated cells (PBMC) separated from non-celiac gluten sensitive (NCGS) patients to various cereal sources. Valerii M.C. et al., Food Chemistry. 2015, 176: 167-174.
  13. An organic khorasan wheat-based replacement diet improves risk profile of patients with acute coronary syndrome: a randomized crossover trial. Whittaker A. et al., Nutrients 2015, 7, 3401-3415.
  14. Antioxidative and anti-inflammatory effect of in vitro digested cookies baked using different types of flours and fermentation methods. Valli V. et al., Food Researh International - in press, available online 11 December 2015.
  15. An interlaboratory comparative study on the quantitative determination of glyphosate at low levels in wheat flour. Simonetti et al., Journal of AOAC International 2015 Dec; 98(6): 1760-8.
  16. A Khorasan Wheat-Based Replacement Diet Improves Risk Profile of Patients with Diabetes Mellitus Type 2: A Randomized Crossover Trial. Whittaker A. et al., European Journal of Nutrition 2016, in press.