Paul Cotter

Current affiliation:
Teagasc Food Research Centre, Moorepark, and APC Microbiome Institute, Cork, Ireland

Title of presentation:
Modulation of the Gut Microbiota Using Bacteriocin-producing Strains

Short Biography(5-10 sentences):
Dr Paul Cotter is Principal Research Officer at Teagasc Food Research Centre, Ireland. He is a molecular microbiologist, with research in his lab focusing particularly on the study of microbial populations in the food chain and in the gut and on antimicrobial peptides for food preservation and gut microbiota modulation. Dr Cotter also manages the Teagasc DNA sequencing facility. Dr Cotter’s laboratory are past winners of the Irish Food/Agriculture Laboratory of the Year Award, he has received awards from the Society for Applied Microbiology, ESCMID and FEMS, is an appointed faculty member of Faculty of 1000 (Biology) since 2006 and is a Principal Investigator with the APC Microbiome Institute since 2009. Dr Cotter is also the author of >200 peer-reviewed publications resulting from research funded by the EU, Science Foundation Ireland, the Irish Health Research Board, Enterprise Ireland, the Irish Department of Agriculture, Fisheries and Food and the Irish Research Council for Science Engineering and Technology.

Current Research: 
Research in the Cotter laboratory focuses on (i) bacteriocins and bacteriocin-producing probiotics, (ii) the study of gut microbes and their contribution to health (as influenced by diet and exercise) and disease and (iii) the microbiology of fermented foods and of the food chain.

Selected recent publications(10):

  1. Bourrie, B.C.T., B.P. Willing, P.D. Cotter*. 2016. The other healthy whole ‘grain’: Microbiota and health promoting characteristics of the fermented beverage Kefir. Front. Microbiol. 7:647
  2. Guinane, C.M., Lawton, E.M., P.M. O’Connor, O. O’Sullivan, C. Hill, R.P. Ross, P.D. Cotter*. 2016. The bacteriocin bactofencin A subtly modulates gut microbial populations. Anaerobe. 40:41
  3. Romano S., Fernàndez-Guerra A., Reen F.J., Glöckner F.O., Crowley, S.P., O'Sullivan O., Cotter P.D., Adams C., Dobson A.D.W. and O'Gara, F.. 2016. Comparative genomic analysis reveals a diverse repertoire of genes involved in prokaryote-eukaryote interactions within the Pseudovibrio genus. Front. Microbiol. 7:387
  4. Pereira-Fantini PM, Bines JE, Lapthorne S, Fouhy F, Scurr M, Cotter PD, Gahan CG, Joyce SA. Short bowel syndrome (SBS)-associated alterations within the gut-liver axis evolve early and persist long-term in the piglet model of short bowel syndrome. J Gastroenterol Hepatol. 2016 Mar 31. Epub
  5. Fouhy F, Clooney AG, Stanton C, Claesson MJ, Cotter PD.*. 2016. 16S rRNA gene sequencing of mock microbial populations; impact of DNA extraction method, primer choice and sequencing platform BMC Microbiol 16:123.
  6. Field, D., O'Connor, R., Cotter P.D, Ross, R.P. and Hill, C. 2016. In vitro activities of nisin and nisin derivatives alone and in combination with antibiotics against Staphylococcus biofilms. Front Microbiol. Accepted.
  7. Mathur et al. 2016. Flow cytometry as a tool to study the effects of bacteriocins on prokaryotic and eukaryotic cells. Journal of Molecular Biomarkers & Diagnosis. Accepted.
  8. Field D, Cotter PD, Hill C, Ross RP. 2015. Bioengineering Lantibiotics for Therapeutic Success. Front Microbiol. 6:1363.
  9. Guinane, C.M., C. Piper, L.A. Draper, P.M. O’Connor, C. Hill, R.P. Ross, P.D. Cotter*. 2015. Impact of environmental factors on bacteriocin promoter activity in gut-derived Lactobacillus salivarius. Appl Environ Microbiol. 81:7851-9.
  10. Walsh CJ, Guinane CM, Hill C, Ross RP, O'Toole PW, Cotter PD*. 2015. In silico identification of bacteriocin gene clusters in the gastrointestinal tract, based on the Human Microbiome Project's reference genome database. BMC Microbiol. 15:183.