HEALTH BENEFITS OF PROBIOTICS BY IMPACTING INTESTINAL BARRIER FUNCTION
Garcia Rodenas C., Bron P., Kleerebezem M., Brummer R., Cani., Wells J.
Wageningen University, Wageningen, The Netherlands
Intestinal barrier integrity is a prerequisite for homeostasis of mucosal function, which is balanced to maximized absorptive capacity, while maintaining efficient defensive reactions against chemical and microbial challenges. Evidence is mounting that disruption of epithelial barrier integrity is one of the major etiological factors associated with several gastrointestinal diseases, including infection by pathogens, obesity and diabetes, necrotising enterocolitis (NEC), irritable bowel syndrome (IBS), and inflammatory bowel disease (IBD). The notion that specific probiotic bacterial strains can impact barrier integrity fuelled research in which in vitro cell lines, animal models and clinical trials are employed to assess whether probiotics can revert the diseased state back to homeostasis and health. This review catalogues and categorizes the lines of evidence available in literature for the role of probiotics in epithelial integrity and, consequently, their beneficial effect for the reduction of gastrointestinal disease symptoms.
Keywords: Mucosal integrity, Probiotics, Intestinal disorders, Allergy, Metabolic syndrome
Garcia Rodenas C., et al. (2016). Health benefits of probiotics by impacting intestinal barrier function. Conference Proceedings of IPC2016. Paper presented at the International Scientific Conference on Probiotics and Prebiotics, Budapest (p. 26.). IPC2016